Saturday, January 22, 2022

 Headache for Anaesthtists:

PDPH is sometimes severe and disabling, WHEN THE HEAD ACHE CONTINUES BEYOND nearly 2 weeks, it makes the heache for Anaesthetist as well.
The patient still blames the anaesthetist for her brain problem, May be she was right . Here is the analysis.
CASE REPORT AND ANALYSIS:
A 40 yr old Lady, ASA-I ,with no co morbidity was posted for Vaginal Hysterectomy under Spinal Anaesthesia. Her Hb,DC,TLC,Platalate,Urea Creatinine, Na, K were all in normal limit.
After an IV line established 500ml NS given Her BP was 134/88 HR 90/min SpO2 99% and a sitting spinal was done successsfully in a single attempt with a 25G needle when CSF was clear and normal pressure, Bupivivaine heavy 2.8 ml was adminstered, After positioning Blood pressure dropped to 92/66 and an Injection Ephedrine 5 mg 2 doses was given IV and the BP rose to 140/86. Rest of intra op was uneventful
She developed headache about 24 hrs later, which was positional and diagnosed as PDPH, She was reassured by Nursing staff that it happens sometimes after Spinal injection and will disappear in 2-3 days, along with Paracetamol 1gm BD ,advised to lie down more as it was positional. It improved in next 3-4 days and she was discharged.
About 5 days later at home she again she developed headache the intensity increased , It was disabling with disturbed sleep and other activity , there was more pain in nape of neck, and some rigidity. She was readmitted to the hospital which was exclusively an obst and Gyn Hospital. The Anaesthetist was consulted
O/E it was found she was in distress, had some fever for 3-4 days, The head ache was disabling and no more positional There was neck rigidity, TLC count 14000.A differential diagnosis of re appearnce of PDPH, Meningigm, Meningitis, SAH was suspected.
When she was asked for a repeat spinal puncture and CSF analysis for presence of blood and/or cell count, she vehemently refused. So she was referred to a nearby Neuro center for a CT scan which confirmed the diagnosis of SAH. ( PIC -1 ). The neuro surgeon further advised a CT angio which confirmed an Anneurism in MCA ( middle cerebral artery ) area, ( PIC-II) which was clipped next day and the patients head ache decreased and in 7 days she was back to normal.
ANALYSIS: Major Neurologic complecations following Spinal anaesthesia is not common, but headache,Septic and aseptic meningitis,Arachnoiditis, Myelitis, Chordaequina syndrome are known since long , reported as early as 1946 ( JAMA 1946 ;132 (12) 679-685)
Risk factor for PDPH: (1) younger age, (2) pregnancy, (3) use of largebore needle. Theory for PDPH is Bimodal, a) Low Spinal fluid volume b) relative vasodilation in response to stretching intracrannial anchoring structure.
General Anaesthesia is advocated in Anneurism with control of mean arterial pressure, airway protection and Oxygenation.
There are plenty of case reports of Anneurism rupture after Spinal Anaesthesia.
Anaesthetists from Basil, successfully manages a known case of Giant Aneurism with Epidural Anaesthesia with out any complication .
They have explained that the Aneurism is at danger of rupture if the differential pressure of ( Transmural aneurism pressure) ( MAP) – Intra cranial Preessure( ICP ) increase by either raise in MAP or fall in ICP after fall in CSF pressure that raises Intramural pressure.
So a fluctuation of BP resulting in high intramural pressure against a low intracrannial pressure following Spinal Anaesthesia and csf leak could have resulted the rupture of Annurysm.

Thursday, January 30, 2020

My first Anaesthesia as a Professional

My first Anaesthesia
MY FIRST ANAESTHESIA AND PRIVATE PRACTICE 

During my PG study at SCB Medical College,way back in eighties, I was staying in hostel but used to come home often at 4,Gautam Nagar, Bhubaneswar, that was my fathers official residence.
During that time Dr S N Mohanty who was 2 years senior to us but finished MBBS and internship along with us had started a nursing home, Sunder Nursing Home  probably the 1st Nursing home of Capital city , Bhubaneswar. A very small one compared to many at present with just 6-7 cabins, a reception, an OT, two doctors chamber.
 Prof A M Naik FRCS, a renouned surgeon of that time used to operate in the nursing home. We being friendly during undergraduate Medical college, used to visit the nursing home occasionally.
 One-day he asked me, “Prasanna, why do not you give anaesthesia here”, by that time I had  finished  my Post Graduation in Anaesthesia theory exam and about to appear my , oral and practical examination.
“OK, what is the case, ?”
“ A 12 year old boy with cystic hygroma in neck”. “Sir will do it tomorrow evening” He added.
“I am sure you can do it”.
 I agreed. During that time Ether, rather open ether Anaesthesia was widely practised. Boyle’s Anaesthesia machine was available only in Medical colleges. Practising Anaesthesiologists at Cuttack used an Air ether apparatus. A simple device with provision of air flowing in one direction only with an exhalation valve. I did not had one. 
“Open ether will be Ok with Sir “ I asked. 
“No problem with sir, as you decide”, he replied.
 Nextday while returning from SCB Medical college, I purchased a tea strainer from Ranihat, a bottle of ether. Reached Nursing home, much before time. Saw the boy and checked if he has any cough and cold. Saw a medium size swelling in the neck right side. Auscultated his heart and lungs. No ECG, No evaluation and clearance by cardiologist. We have our own tests to evaluate a normal cardiac status. I do not remember what kind of blood tests were done. But surely a stool and urine test. Probably a DC and Hb was enough.
 Everything looked normal. The parents were more anxious than the boy. Prof Naik was supposed to reach around 5.30 pm. 30 mins before I gave an injection of atropine 1 amp ingluteus muscle in his room. When Prof Naik arrived in his car  the boy was called into OT room. I do not remember if We had started an IV drip or not.
 Hesitantly he came into the room. With a little coaxing he was made to sit on the table eagerly looking all around. All new faces and covered with a white mask. He was made to sleep on the table with a little force. By that time I had cut the plastic handle of the tea strainer , it became a rounded mask and I covered it with 4 layers of gaudge piece. When I brought in the face mask towards the face the pungent odour made him move his head away. I had to fix his head as well as put ether drops on the mask at a rate of approximately 100 drops / min.There were 2-3 assistants who restrained his legs and hands.It was not a easy job. He held his breath for some time then cried out. Initially one needs high concentration. He cried and pleaded to leave him, the more he cried more ether vapour he inhaled. I could feel the strong ether vapour coming out during his expiration. I continued my act like an expert knowing my job fully well.Within a minute the boy was motionless and breathing spontaneously without any fight. An I.V line was placed on his forarm and a bottle of Glucose saline was started. There was no venous cannula during that time. Glucose saline flowed drop by drop through a needle that was fixed into the vein. Some one was assigned to hold that hand , probably tied to the table.
 I poured more ether drops to continue and reach a surgical stage, that was known from the pattern of respiration. There was no ECG monitor or SpO2 probe. In between we checked the radial pulse or near the head superficial temporal artery pulsation. 
 Prof Naik who was ready by that time with Surgeons glove and dress came to table applied antiseptic on the part and covered the site with sterile clothes.In those times the clothes were autoclaved but the instrument is were boiled in water for 30-40 mins. That was a little discomfort as we shared the head end of the patient to work. Before he put incision he looked at me, I had added more ether to suppress the reaction to incision. I nodded my head in positive,though I was a bit anxious as well. The incision was painless and there was no movement, I silently breathed heavily.
 Ether is a volatile anaesthetic, it quickly evaporates at room temperature. From the face mask the patient breathes in this vapour and anaesthetised. While exhaling the same vapors fill the room air but gets diluted and does not ffect us unless one puts his head close the the face mask. Many a times ice is formed in between the layers of gauze , as the moisture from expired gas becomes wet and ice forms and obstructs the flow of air. Like an expert I knew when to change these layers and put new ones.
 In between I had to check his pulse and look at his pupil to estimate the depth of Anaesthesia along with type of respiration, that guides us when to stop or add more of ether drops on to the mask to maintain optimum anaesthesia state for the surgery. More importantly there is a trick to hold the mask so that he breaths easily, as in an unconscious patient the tongue falls and one can not breath properly. That also strains my left hand. I do not remember  applying an airway ,( a metallic curved device placed in side mouth that prevents fall of tongue, we use these days often a plastic one)
 Luckily for me this patient needed lesser depth than a surgery in Abdomen. This adminstartion of ether vapour is a continuous process that needs balance , and this one lasted for about 30 mins. Prof Naik was a great surgeon no doubt.He did his job precisely and removed the liquid filled tumour along with its walls from the neck,He was assisted by only one nurse.The bleeding vessels were tied with cat gut almost obsolete these days. Also application hot tetra ( 4 layers of gauge stitchedtogether,size of a handkerchief) .Finally the skin which was cut for about 4 to 5  fingers long was closed with skin stitch with simple cotton thread sterilised by puting it in boiled water for 10-15 mins.
 Towards the end of stitch before applying  a skin ointment and surgical dressing, I stopped and removed the mask from his face and felt his breath clearly as as lifted this chin and head  a bit for unobstructed breathing. About 15 mins later his breathing pattern also changed slightly, When I pinched his ear lobule he responded with movement of hands after a while the boy cried a kind of soft moan. In another 5 mins he cried. Thats when I gave a sigh of relief. My patient is OK, and I remembered the age old dictum, “Patient cries ,Anaesthetist Laughs” .
Prof Naik who by that time had removed his OT dress and gloves, came in looked at the patient then looked up at me, said with his style of a smile “That was a good going, very good”. He felt his pulse , “How long it will be for recovery?”. 
“May be 15-20 mins, we will shift him to his room”, I responded. “OK then”, he said
 I asked the patient to be shifted to the cabin, Parents were happy to see their boy but still a little gloomy as the boy was still sleeping .We put him to  one side (lateral position), to have a better breathing as well as prevent  any aspiration if there is vomiting. Vomiting is very common after ether Anaesthesia. We also told the parents and watching sister that this happens during recovery of Anaesthesia. The parents had a lot of querries in their eyes, when the surgeon came in. He felt his radial pulse and checked his bandage. 
He declared, “The operation has gone well, There  is no bleeding, everything is fine”.
Wheather he addressed  to all medical staff or to the patients attendants difficult to say. The father bent to touch the feet of the surgeon. After Prof Naik left the father appeared to be satisfied.
I also confirmed,” Do not worry everything is fine”.
I advised, to give an injection of Pethidine  and Phenergan  intra muscular after complete recovery. IV fluids and Antibiotics were domain of surgeon. 
"He will sleep for next 6 hours with these", I told the parents.
 I left the room and came to doctors chamber along with Dr Mohanty. Soon a cup of  tea was served which I finished in two three gulps as it was nearly cold now. While chit chatting on some other things Dr Mohanty unlocked and opened his drawer , brought out a fifty rupees note as my professional fees. That was my first professional earning, which I put it in my pocket happily and carefully. I  thanked Dr Mohanty. 
Even though I had adminstered anaesth to patients being operated by many other professors in Medical College, at Cuttack , independently, that was a different experience for me, not because of the money I earned but administered anaesthesia to a patient operated by Prof Naik outside the Govt hospital. Prof Naik was a different and respected surgeon all over Odisha. Dr Morton the inventor of Anaesthesia must have felt like that in October 1846, a victory.


Note: Some names changed. Now I understand after a visit to USA hospital, sometimes an anaesthetist fees are more than the surgeons.

Monday, December 31, 2018

Analysis of Life after Deathg: NDE


                   


                         The topic is NDE- an analysis of LIFE after Death   

Dear Reader click on the link  and watch the VDO till end to learn about Life after death.
Please leave a comment .



                       
https://photos.google.com/album/AF1QipOAHxpwkkzlgHHj7By5VDf5DzSRREu7HmEAuzYc/photo/AF1QipN0gf-9DWo3

ruGnb3zp-ZCsqopqPYO_2fDpM7kx

Wednesday, July 19, 2017

Very large p wave ..in LEG monitor for diagnosis of correct cvp line placement

This ECG with extra large p wave can be seen only when you place your lead in the Right atrium.
Therefore when one inserts the CuP line from the sub clavian vein this is one of the good ways to know that the tip of the CVP is in RA. Very rarely the CVP tip may go upwards or to opposite side of sub clavian vein which can be detected only by an X-Ray chest later on.
Another way to know correct placement is by detection of an supra ventricular extra systole when the guide were is manipulated.
A third method is to connect the CVP to a pressure transducer and detect typical upward "abc" and downward "xy" waves.

Sunday, April 16, 2017

Low Oxygen Saturation without visible cause.. immediate post op.

A 55 year old Female patient was posted for Lap Cholecystectomy.
She was healthy 72 kg. Slightly over weight. No known problem with Diabetes, Hypertension or bronchial asthma. She was hypothyroid which was controlled with 5 years. Her ASA status was ASA-I with clear airway and Mallampaty score I
                           She was premedicated with Midazolam 3 mg and Pentazocine 30 mg.The  induction of anaesthesia  that was done with Atropine, Propofol, Scholine sequence with easy intubation.
Anaesthesia was maintained with N2O :O2 at 66:33 ratio  Vecuronium and Isoflorane 0.8-1 %.
There was mild fluctuation of blood pressure during gas insufflation . The operation was uneventful duration of operation was less than 30 mins . At the end of surgery and when some resp effort was noticed she was revered with usual 2,5 mg prostigmine and 1,2mg atropine.
She was extubated  after suction of mouth and airway. With in 10 mins she was alert and responding. Her breathing resp effort was normal with good forceful breathing on command. After some Oxygen inhalation 100% with mask for 2-3 mins she was sent to recovery room, where she was given Oxxygen by mask she appeared to be comfortable with no indication of pain or discomfort in abdomen / operated area.
                        After some time her Oxygen saturation slowly came down to 91-95 % in spite of oxygenation and her flow was increased to 6 litres. She was propped up in bed to 45 degree. She appeared to be alert  not in  distress or sedated. On command she could increase the tidal volume and obey command with respect to movement of limbs and over the next 20-30 mins her SpO2 remained unchanged at around 90~92% with Oxygen supplementation.
On enquiry she revealed no discomfort or distress.  Resp rate was around 18~ 22/min with good tidal volume. She said she is more comfortable in sitting up position with head up tilt of more than 60 degree and she often sat up in bed.  This indicated some airway obstruction. She neither had any broncho spasm wheeze or stridor. An injection of hydro cortisone 100 mg was given I V.emperically.
She was left in recovery for ne with close observation of vital parametres.
                    About 1 hrs later  she suddenly had a bout of  vigorous cough  and a thick sputum block was coughed out. Lo her Oxygen saturation was back to 100 % in minutes.
The sptum that was causing if any obstruction was not detectable by clinical means  with auscultation , nor the patient could feel the sputum causing any discomfort.
                    At the end of the day I will  feel like blaming injection atropine that makes the sputum thick  and can make a disaster at times like this.



                      

  

My publications and presentation

PUBLICATIONS & Presentations
Respiratory Embrassmentand delay in recoery following GA ina patient
of congenital Rubella syndrome- A Case Report
Ind J Anaesthesia  2001 Vol 45 ( 4 ) :p 298
2  Letter to Editor - Anaesthesia for cong rubella Syndrome
Ind J Anaesthesia 2002 Vol 46 ( 1 ) :p 64
Ind J Anaesthesia  2002 Vol 46 ( 3) : p 226
Efficacies and Inefficiencies in Different Anaesthesia Machines
Ind J Anaesthesia 2002 Vol 46 ( 5) 
Letter to Editor : Accidental Injection of Large doses of Neostigmine Methyle sulphate intrathecally
Ind J Anaesthesia 2004 Vol 48 ( 1) : p 64
Homonymus Hemianopia- A coincidence following short General Anaesthesia- A case report
Ind J Anaesthesia 2004 Vol 48 ( 3) : p 228
Letter to Editor: Can N2O cylinder be overfilled ?
Ind J Anaesthesia 2005 Vol 49 ( 5) :p -437
Effect of Oral Gabapentine on post op epidural analgesia
Ind J of Pain. 2009 Vol 23 ( 2) :p 308-312
Letter to Editor- Euthanesia an ethical risk
Ind J of Medical Ethics  2011 Vol 8 ( 4) : p 261-262
9   Burn from DC Defibrillator  a small price to pay- A case report
J Evolution of Med Dent Sci. 2016 ;   Issue(83) ;6226-6227 2016
Pattnaik NK, Mishra PK. 7, DOI: 10.14260/jemds/2016/1406
10  Atypical location of a Right Atrial Myxoma- A case report
Intnl J of Med Res and Pharmaceutical Sci:  Vol 3, Issue12 Dec 2016 :p 1-6
ISSN : 2349-5340 Impact factor ( PIF):3.109
 Presentations
An Unusual Foreign body in trachea
LMA Whats new
Did I Make a Mistake
Acid baseBalance - Management of Resp Acidosis
Do you have a choice in Volatile Anaesthetic agents
Newer Management of  Pain 
Anaesthetic implication of prone position in elderly.

Prof Parmanik oration - OSIACON 2016-PURI:   TOPIC: Pains and pleasures in Anaesthesia"


POSTER Acute Lung Injury review of 7 cases
POSTER Acute partial Upper Airway Obstruction & Posture
POSTER THE Unfaithful Slave Valve
POSTER IS PRE LOADING MANDATORY WITH ALL SPINAL ANAESTH
POSTER TURP syndrome ina Non TURP case  

PK Mishra
Signature

Saturday, July 30, 2016

Premature Reversal of musclerelaxation leads to complecation


A female patient  60 years of age  was posted for Lap Cholecystectomy.

On evaluation  the patient had GI problem 2 weeks back with acute cholecystitis, distention , vomiting etc for which she was treated conservatively and was seent back home with advice for early surgery of Gall bladder.


            She was slightly plum with big tummy weighing 68kg. No h/o HTN, but DM type II with blood sugar at 130 mg% was given glucose  and 5 units of Insulin. Her Hb was 11.2gm% TLC 12400, Amylase, LFT, Urea and creatinine , Sodium and Pottasium were within normal limits. During PAC she had more complain about back ache and sciatica type pain than Gall bladder discomfort or pain. Her ECG and cardiac  reserve appeared to be OK clinically with good air entry to both lungs.

            She was given an Injection Diclofenac aqua before surgery so that sciatica pain will diminish and her anxiety will be resolved. She was premedicated  with Midazolam 3 mg. Nalbuphine 20 mg  after 10 mins induced withPropofol 100 mg and intubated with ease with 7.5 mmET tube after succynyl chiline injection of 100mg. Connected to ventilator with low tidal volume of 375mg and resp rate of 20 /min . Injection of Vecuronium initially 3 mg . As a routine pre incision procedure takes about 15 mins  so another 2mg Vecuronium was added at this time a total of 5mg. And Halothane 0.8 % was added. To the FGFlow mixture of O2 nd N2O going at 1.5l to 3.0 L/min

The procedure was uneventful with minimal fluctuation of  Vital parameters of HR, BP, and SpO2. The skin to skin procedure lasted 22 mins. As displayed on the timer clock on the wall of the OT.

As the surgery was over so soon we were waiting for the muscle elaxant to wear off. With O2 and N2O mixture running at 50:50. There was no respiratory effort till next 15 mins. We tried to stimulate the resp with under ventilation and accumulation of CO2 to some extent but not more tham 50 mmHg as shown in ETCO2  monitor. There was no CO2 in expired gas.

At this stage the surgeon wanted to take up another case and finish his OT list and  go to OPD.  But all my effort to stop N2O and stop ventilation for  sometime did not help. With much hesitation half of the mixture of Prostigmine 2.5mg and atropine1.2 mg ( diluted to 10 ml) was given IV. Slowly. In next 5 mins there was a flicker of resp movement in Bag and small CO2 curve appeared and being encouraged with that the rest of the mixture was injected. By this time the next patient was standing by the OT for spinal anaesthesia . More movement of resp  was noticed but still with a high expired CO2 of 60mm. But the coughed on the tube and there was fall in Spo2 even with 100 % oxygen. So the patient was extubated assuming that her respiration will be quiet and will improve over next 5-10 mins. As soon as she was extubated the patient was shifted to trolley and taken to Recovery room to accommodate the next surgical case.

In the recovery room the patients breathing appeared to be inadequate with SpO2 less than 90%. An air way was given respiration was watched . It was found that the patient was showing signs  of incomplete reversal with jerky muscular  movement of limbs and inadequate respiratory movement. A second dose of Neostigmine atropine mixture was given IV . Still there was no improvement. The big abdomen  caused more embarrassment to respiratory function. It was intermittently supported with Ambu bag and mask ventilation. When ever there was some fall in Spo2 a little ambu bagging helped to regain Spo2 to 100 %. In the process it was suspected that there is a stomach is inflated with air and we tried to remove  the air introducuing a feeding tube  and were not sure how much was removed. The presence of feeding tube made the bag mask ventilation difficult and therefore the patient was intubated with a 7.5 mm tube on the recovery trolley as such with out any drug or additional muscle relaxant. As such she resisted a little and intubation was completed with ease .

As we tried several times with a T –piece connection  to maintain resp ,But the respiratory drive  and ventilation did not improve  more Ambu bagging support was needed to main Oxygen saturation and avoid CO2 retention and sweating.  Some secretion appeared in the Et tube at this time it was felt probably the patient has aspirated with some Gastric content during  Ambu and mask ventilation. So the patient was shifted to ICU for full and controlled ventilation.

The patient was initially put on Pressure control with SIMV FiO2  0.5 Pr 20cm Peep of 5 and SIMV rate of 12. IE ratio of 1:2 but spO2 was still low and Ambu ventilation showed better SpO2. So the setting was changed to  Pure pressure control Pr of 20cmH2O PEEP of 10 . f=15 I;E ratio of 1:1.5 FiO2 =0.6.  Over the next 15-20 mins patient was stabilized for SpO2, HR. BP was low because of high Intrathoracic pressure and a rapid fluid and a small dose of nor adrenaline helped.   A small dose of Lasix. Change of Antibiotics  wasdone. By next 4 hrs  the pt was better with  stable vitals and patient looking up. Gradually Fi)2, PEEP and Pressure was reduced after overnight ventilation the patient was extubated  and transferred to Ward with out any hassle.

Analysis:

            1. Fundamentally  the process of reversal should have been initiated after some respiratory activity is seen.

            2. The patient should not have been extubated just because started bucking on the tube.

            3. Re intubation should have been planned earlier

            4. What ever way one ventilate with Ambu bag and mask. There is always chance of air going to stomach.

            5. Chance of Aspiration regurgitation  is highest during this period and can not be ruled out.

            6. Persistent Hypoxic episode  could lead to pulmonary edema.

            7. In this case development of pulm edema could be either of the factors as mentioned above.

Lady who suffered